THE GENETICS & EPIGENETICS THEME
Project 1: Genetic studies
Hypothesis: Genetic determinants of HF phenotypic dimorphism (HFpEF vs HFrEF) exist
- Builds on NMRC TCR-funded work: Genome-wide Association Studies
- Whole genome sequencing (A*STAR-funded)
- HFpEF vs HFrEF
- Quantitative phenotypes: Cardiac MRI, biomarkers
Project 2: Epigenetic studies Modifiable Disease Mechanisms
- Chromatin organization: histone modifications, DNA methylation, lamina-domains
- Do different sub-populations of cardiomyocytes exist?
- What are the novel histone modifications in cardiomyocytes
- Map of the cardiac epigenome of 100 human hearts
- Experimental models of diseases
- Pig model: track progression of disease and its reversibility
Aim: Novel therapeutic targets in cardiac epigenome/chromatin
A*STAR celebrates International Women's Day
From groundbreaking discoveries to cutting-edge research, our researchers are empowering the next generation of female science, technology, engineering and mathematics (STEM) leaders.