PUBLICATIONS & PRESS RELEASES
1. Heart Failure Patients in Asia (Article in Mandarin, 16 Oct 2018)
2. ESC: Evidence grows for HFpEF as microvascular disease (Medpage, August 2018)
3. Industry and academia must work together (Asia-Pacific Biotech News, May 2018)
4. Heart Failure in Women: Taking Control (Roche’s Dia:gram, April 2018)
5. Found: Molecule that stops heart from healing (The Straits Times, 22 Aug 2017)
6. ICD: Utilisation rate in Asia (Murmurs, NHCS, Apr-Sep2017)
7. Heart failure is different in Women (Health, Nov-Dec 2017)
8. New way to detect heart failure that's hard to diagnose (The Straits Times, 21 July 2017)
9. Multinational heart failure study shows high prevalence of coronary artery disease, hypertension and diabetes in Asian patients (Media Release, 16 June 2016)
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Publications
2019
Scientific Reports. 2019 Apr 2;9(1):5532
Scientific Reports, Vol 8, Article number: 7055 (2018)
J Am Coll Cardiol: Basic Translational Science; 2018 May 30;3(2):163-175
Diabetes, Obesity & Metabolism. 5 Dec 2018. DOI: 10.1111/dom.13608
4. Heart Failure With Preserved Ejection Fraction in the Young5. Targeting Chondroitin Sulfate Glycosaminoglycans to Treat Cardiac Fibrosis in Pathological Remodeling
Circulation. 2018 Jun 5;137(23):2497-2513
6. Mortality Associated With Heart Failure With Preserved Versus Reduced Ejection Fraction In A Prospective International Multi-Ethnic Cohort Study
7. Prevalence, clinical correlates and outcomes of anaemia in multiethnic Asian patients with heart failure with reduced ejection fraction
8. Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction
9. Distinctive Molecular Signature and Activated Signaling Pathways in Aortic Smooth Muscle Cells of the Patients with Myocardial Infarction
10. MicroRNA-143 modulates the expression of Natriuretic Peptide Receptor 3 in cardiac cells
11. Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry
12. N-terminal pro-B-type Natriuretic Peptide and Prognosis in Caucasian versus Asian Patients with Heart Failure
13. Chronic obstructive pulmonary disease and β-blocker treatment in Asian patients with heart failure
14. A risk assessment score and initial high-sensitivity troponin combine to identify low-risk of acute myocardial infarction in the emergency department
16. Prognostic Implications of Dual Platelet Reactivity Testing in Acute Coronary Syndrome
18. Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine
19. ICare-ACS (Improving Care Processes for Patients With Suspected Acute Coronary Syndrome): A Study of Cross-System Implementation of a National Clinical Pathway
21. Single-dose Intravenous Iron in Southeast Asian Heart Failure Patients: A pilot randomized placebo-controlled study (PRACTICE-ASIA-HF)
1. The heart regulates the endocrine response to heart failure: cardiac contribution to circulating neprilysin
2. The Prognostic Value of Highly Sensitive Cardiac Troponin Assays for Adverse Events in Men and Women with Stable Heart Failure and a preserved versus a reduced Ejection Fraction
4. Variability in Microplate Surface Properties and Its Impact on ELISA
J Appl Lab Medicine 2017 Oct; Vol. 2, Issue 6
5. Multinational and multiethnic variations in health-related quality of life in patients with chronic heart failure
7. Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo
9. Disparity Between Indications for and Utilization of Implantable Cardioverter Defibrillators in Asian Patients With Heart Failure
10. Metabolic and Blood Pressure Effects of Walnut Supplementation in a Mouse Model of the Metabolic Syndrome
11. Characterization and Standardization of Cultured Cardiac Fibroblasts for Ex Vivo Models of Heart Fibrosis and Heart Ischemia
12. Mortality and acute exacerbated COPD: a pilot study on the influence of myocardial injury
13. Ankyrin repeat domain 1 protein: A functionally pleiotropic protein with cardiac biomarker potential
14. Thymosin beta-4 is elevated in women with heart failure with preserved ejection fraction
15. Risk Stratification Model for 30-day Heart Failure Readmission in a Multi-ethnic South East Asian Community
16. Risk stratification of Asian patients with Heart Failure and Reduced Ejection Fraction:The effectiveness of the 'Echo Heart Failure Score'
17. Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction
19. Transitioning from Usual Care to Biomarker-Based Personalized and Precision Medicine in Heart Failure: Call for Action
20. Prevalence and Clinical Significance of Diabetes in Asian Versus White Patients With Heart Failure
21. A landscape of circular RNA expression in the human heart
24. Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction
J Control Release. 2017 Feb 10; 247:127-133
2016
1. Pulmonary hypertension in heart failure with preserved ejection fraction: a plea for proper phenotyping and further research
Eur Heart J. 2016 Dec 23. 0:1-5
2. Right ventricular dysfunction in heart failure with preserved ejection fraction: a systematic review and meta-analysisEur J Heart Fail. 2016 Dec; 18(12):1472-1487
3. Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Association With Exercise Capacity, Left Ventricular Filling Pressures, Natriuretic Peptides, and Left Atrial VolumeJACC Heart Fail. 2016 Dec. 5(2):92-98
4. Prevalence and Clinical Significance of Diabetes in Asian Versus White Patients With Heart Failure
JACC Heart Fail. 2016 Nov 30; S2213-1779(16):30501-7
5. The International Human Epigenome Consortium: A blueprint for scientific collaboration and discovery
Cell. 2016 Nov 17; 167(5):1145-1149
6. Heart Failure With Preserved Ejection Fraction and Atrial Fibrillation: Vicious TwinsJ Am Coll Cardiol. 2016 Nov 15; 68(20):2217-2228
7. Serum ferritin and risk for new-onset heart failure and cardiovascular events in the communityEur J Heart Fail. 2016 Oct 19; 19(3):348-356
8. Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac HypertrophySci Rep. 2016 Oct 12; 6, article number:35247
9. Influence of Ethnicity, Age, and Time on Sex Disparities in Long-Term Cause-Specific Mortality After Acute Myocardial Infarction
J Am Heart Assoc. 2016 Oct 6; 5(10)
JAMA Cardiol. 2016 Oct 1;1(7):823-824
11. A simplified, Landendorff-free method for concomitant isolation of viable cardiac myocytes and non-myocytes from the adult mouse heartCirc Res 2016 Sep 30;119(8):909-20
12. Ethnic differences in the association of QRS duration with ejection fraction and outcome in heart failure
Heart. 2016 Sep 15;102(18):1464-71
J Am Coll Cardiol. 2016 Aug 9; 68(6):639-53
14. Regional and ethnic differences among patients with heart failure in Asia: the Asian sudden cardiac death in heart failure registry15. A genomic and epigenomic comparison of fetal and adult human cardiac fibroblasts reveal novel key transcription factors in adult cardiac fibroblasts
JACC Bas Trans Sci. July 2016; 1(7):590-602
16. Three-Dimensional Tricuspid Annular Motion Analysis from Cardiac Magnetic Resonance Feature-TrackingAnn Biomed Eng. 2016 Jul 19; 44(12):3522-3538
17. AAV9 delivery of shRNA to the mouse heart Curr Protoc Mol Biol. 2016 Jul 1; 115:23.16.1-9Current Opinion in Cardiology, Jul 2016, 31(4):410-416
19. High-Sensitivity Sandwich ELISA for PlasmaNT-proUcn2: Plasma Concentrations and Relationship to Mortality in Heart FailureClinical Chemistry 2016 Jun; 62(6):856-865
20. Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps
JACC Heart Failure 2016 June; 4(6):419-427
21. Association of Age, Sex, Body Size and Ethnicity with Electrocardiographic Values in Community-based Older Asian AdultsHeart Lung and Circulation 2016 Jul; 25(7):705-11
22. Understanding Heart Failure With Mid-Range Ejection FractionJACC Heart Failure 2016 Jun; 4(6):473-476
23. Paradoxical Low Gradient Aortic Stenosis: The HFpEF of Aortic Stenosis
Journal of the American College of Cardiology 2016 May; 67(20):2447-2448
24. Intra-Left Ventricular Flow Velocity Distributions, Based on Color Doppler Echo Vector Flow Mapping of Normal Subjects and Heart Failure PatientsCardiology Science and Technology 2016 May, Chapter 14, 391-411
Biochem Biophys Res Commun. 2016 May 20; 474(1):168-74
26. Overview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis
Int J Mol Sci. 2016 May 18;17(5)
27. Discovery of Potential Therapeutic miRNA Targets in Cardiac Ischemia-Reperfusion Injury
J Cardiovasc Pharmacol Ther. 2016 May;21(3):296-309
28. Cardiac MRI based numerical modeling of left ventricular fluid dynamics with mitral valve incorporated
J Biomech. 2016 May 3;49(7):1199-205
29. Longitudinal Community-Based Study of QT Interval and Mortality in Southeast Asians30. MicroRNA and Heart Failure
Int J Mol Sci. 2016 Apr 6; 17(4):502
31. The ethnicity-specific association of biomarkers with the angiographic severity of coronary artery disease
Neth Heart J. 2016 Mar; 24(3):188-98
J Am Heart Assoc. 2016 Mar 25;5(3)
33. Incidentalome from Genomic Sequencing: A barrier to personalized medicine?EBioMedicine. 2016 Feb 4; 5:211-216
34. Microvascular endothelial dysfunction in heart failure with preserved ejection fractionHeart. 2016 Feb 15; 102(4):257-9
35. Connecting Heart Failure with Preserved Ejection Fraction and Renal Dysfunction – The Role of Endothelial Dysfunction and InflammationEuropean Journal of Heart Failure 2016 Feb 10; 18(6):588-98
36. Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort37. Breakthrough in heart failure with preserved ejection fraction: are we there yet?
2015 and beyond
1. Automated quantitative assessment of cardiovascular magnetic resonance-derived atrioventricular junction velocities
Am J Physiol Heart Circ Physiol. 2015 Dec 1; 309(11):H1923-35
JACC: Heart Failure Epub 2015 Dec 2
3. Variational Reconstruction of Left Cardiac Structure from CMR Images
PLoS One. Dec 2015;10(12):e0145570
4. Rationale and Design of a Pilot Randomized Controlled Trial to Assess the Role of Intravenous Ferric Carboxymaltose in Asian Patients with Heart Failure (PRACTICE-ASIA-HF)
ESC Heart Failure Epub 2015 Dec 16
5. Vascular Health Indices and Cognitive Domain Function: Longitudinal Ageing Studies
Journal of Alzheimer's Disease 2015 Nov 26; 50(1):27-40
6. The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease
Expert Review of Molecular Diagnostic, 2015 Nov 04; 15(12):1577-1588
Medicine (Baltimore); 2015 Nov; 94(45)
8. Growth Differentiation Factor 15 in Heart Failure with Preserved versus Reduced Ejection Fraction
Eur J Heart Fail Epub 2015 Oct 25
9. FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy Int J Cardiol 2015 Sep 15; 195:85-94
10. Women Undergoing Coronary Angiography for Myocardial Infarction or Who Present With Multivessel Disease Have a Poorer Prognosis Than Men
Angiology 2015 Sep 7
11. Electrocardiographic Criteria for Left Ventricular Hypertrophy in Asians Differs From Criteria Derived From Western Populations—Community-based Data from an Asian Population.
Ann Acad Med 2015 Aug; 44(8):274-283
12. Cardiac Endothelium-Myocyte Interaction: Clinical Opportunities for New Heart Failure Therapies Regardless of Ejection Fraction
Eur Heart J 2015 Aug 14; 36(31):2050-2060
13. Diabetic Cardiomyopathy: An Expression Of Stage B Heart Failure With Preserved Ejection Fraction
Diabetes & Vascular Disease Research Jul 2015, Vol. 12(4):234–238
14. The Relationship among Carotid Artery Remodeling, Cardiac Geometry, and Serum N-terminal Pro-B-type Natriuretic Peptide Level in Asymptomatic Asians: Sex-differences and Longitudinal GEE study.
PLOS ONE 2015 Jul 1; 10(7)
15. Inter-Ethnic Differences in Quantified Coronary Artery Disease Severity and All-Cause Mortality among Dutch and Singaporean Percutaneous Coronary Intervention Patients
PLOS ONE 2015 Jul 6; 10(7)
16. Heart Failure In Southeast Asia: Facts And Figures (Invited Editorial)
ESC-Heart Failure June 2015, Issue 2, Volume 2:46-49
17. Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B
J Mol Cell Cardiol 2015 May; 82:174-83
18. Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100
J Mol Cell Cardiol 2015 May; 82:13-21
19. Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction
Eur J Heart Fail. 2015 Apr;17(4):393-404
20. Patient Selection in Heart Failure With Preserved Ejection Fraction Clinical Trials
J Am Coll Cardiol 2015, 65(16):1668–1682
21. Heart failure with preserved ejection fraction in women: the Dutch Queen of Hearts program
Neth Heart J. 2015 Feb; 23(2):89-93
22. Iron deficiency in a multi-ethnic Asian population with and without heart failure: prevalence, clinical correlates, functional significance and prognosis
23. Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry
24. The Heart Failure Outcomes and Phenotypes (SHOP) Study and Prospective Evaluation of Outcome in Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (PEOPLE) Study: Rationale and Design
25. Growth differentiation factor 15, ST2, high-sensitivity troponin T, and N- terminal pro brain natriuretic peptide in heart failure with preserved vs. reduced ejection fraction
Posters
1. Left atrial strain by cardiac magnetic resonance feature tracking is a novel diagnostic biomarker of heart failure with preserved ejection fraction
3. Role of Chronic Inflammation in Driving Progression of Heart Failure
CYTO Asia 2017
4. SG10K: Insights into the genetic architecture of Singaporeans
ASHG 2017
American Heart Association 2017
Conf Proc IEEE Eng Med Biol Soc. 2015;2015:319-22
9. Automatic localization of mitral valve orifice in three-dimensional left cardiac model
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