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The disclosure relates to novel markers of pluripotent stem cells and uses thereof, and particularly, though not exclusively, to antibody molecules based on fragments of mAb84 which bind to undifferentiated pluripotent stem cells via podocalyxin-like protein-1 (PODXL).

There is provided at least one isolated TCR-like antibody or fragment thereof, wherein the antibody or fragment thereof is capable of specifically binding to at least one HBV derived peptide.

According to one aspect, there is provided a method for assessing the treatment of attention-deficit/hyperactivity disorder (ADHD) in a subject, the method comprising: obtaining electroencephalographic (EEG) data relating to a plurality of subjects diagnosed with ADHD; extracting, for each of the plurality of subjects, at least one feature from the EEG data relating to that subject; formulating a prediction model by performing regression analysis to map the extracted features against one or more markers for each of the plurality of subjects; and determining that the prediction model provides an ADHD assessment if one or more of the markers are indicators of a clinical measure of interest.

A microfluidic droplet generator device, a kit of parts for assembling a microfluidic droplet generator device, and a method of generating microfluidic droplets. The generator device comprises a substrate; a microfluidic channel formed in the substrate; a fluid outlet in fluid communication with the microfluidic channel; and a mechanical element configured such that vibration of the mechanical element causes droplet dispensing from the fluid outlet.

According to embodiments of the present invention, a method for forming an optical modulator is provided. The method includes providing a substrate, implanting dopants of a first conductivity type into the substrate to form a first doped region, implanting dopants of a second conductivity type into the substrate to form a second doped region, wherein a portion of the second doped region is formed over and overlaps with a portion of the first doped region to form a junction between the respective portions of the first doped region and the second doped region, and wherein a remaining portion of the second doped region is located outside of the junction, and forming a ridge waveguide, wherein the ridge waveguide overlaps with at least a part of the junction.

According to embodiments of the present invention, a frequency shift keying transmitter is provided. The frequency shift keying transmitter includes a logic gate arrangement that produces an output signal having a frequency that depends on input signals to the logic gate arrangement, a clock generator coupled to the logic gate arrangement, the clock generator adapted to produce a clock signal, and a sampling arrangement coupled to the logic gate arrangement, the sampling arrangement adapted to receive a data signal, wherein the sampling arrangement is configured to sample the clock signal to generate periodic waveforms delayed from each other by an interval determined by the point the clock signal is sampled, wherein the sampling arrangement is configured to be controlled by the data signal to have the logic gate arrangement select periodic waveforms that are delayed from each other by one of a set of intervals associated with the data signal, to be used as the input signals to the logic gate arrangement to produce the output signal.

A method and apparatus for detecting underwater sounds is disclosed. An embodiment of the apparatus includes a substrate with a vacuum-sealed cavity. A support structure and an acoustic pressure sensor are situated on the substrate. The support structure of the apparatus may include a first oxide layer situated on the substrate, a silicon layer situated on the first oxide layer, and a second oxide layer situated on the silicon layer. The acoustic pressure sensor of the apparatus includes a first electrode layer situated on the substrate, a piezoelectric layer situated on the first electrode layer, and a second electrode layer situated on the piezoelectric layer. In one embodiment, the surface area of the second electrode layer is between about 70 to 90 percent of the surface area of the piezoelectric layer. In various embodiments, the support structure is thicker than the piezoelectric layer.

A piezoelectric sensor comprising a piezoelectric film formed on a surface of an object to be monitored; a plurality of electrodes formed on a surface of the piezoelectric film; and wherein electrical polarization of the piezoelectric film is about coplanar with the surface of the piezoelectric film. A method of forming a piezoelectric sensor. The method comprises forming a piezoelectric film on a surface of an object to be monitored; forming electrodes on a surface of the piezoelectric film; and orientating electrical polarization in the piezoelectric film to be about coplanar with the surface of the piezoelectric film.

Methods for malignant glioma diagnosis/prognosis using miR-138 as a prognostic biomarker and methods for treating malignant glioma and inhibiting glioma stem cell growth by suppressing miR-138. Also disclosed herein are pharmaceutical compositions for use in treating malignant glioma, prolonging survival of malignant glioma patients, or eliminating GSCs and in turn tumor growth, the pharmaceutical composition comprising an oligonucleotide that targets miR-138.

BINDING MOLECULES AGAINST CHIKUNGUNYA VIRUS AND USES THEREOFAbstractThe invention relates to binding molecules against Chikungunya virus, which are able ofneutralizing Chikungunya virus infectivity, and which can be used with therapeutic, diagnosis orresearch purposes, as well as to a pharmaceutical composition comprising said binding molecules.FIGURE 4