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The present invention relates to a method for determining the presence or absence of at least one promoter in a cancerous biological sample relative to a non-cancerous biological sample. The present invention also relates to a method for determining the prognosis of cancer in a subject, a method for modulating the activity of at least one cancer-associated promoter in a cell, a method for modulating the immune response of a subject to cancer, a method for determining the presence of at least one cancer-associated promoter in a cancerous biological sample relative to a non-cancerous biological sample and a biomarker for detecting cancer in a subject.

According to various embodiments, there is provided a heat sink including: a heat conducting surface; a plurality of nozzle arrays arranged such that output ends of nozzles of the plurality of nozzle arrays face the heat conducting surface; and a plurality of fins configured to at least partially surround a respective portion of the heat conducting surface facing a respective nozzle array of the plurality of nozzle arrays.

An apparatus for microfiltration and a scalable method for manufacture of an inertial microfluidic device for such microfiltration apparatus are provided. The apparatus for microfiltration includes one or more inertial microfluidic devices, each including a plurality of spirals of a microfluidic channel. At least one of the inertial microfluidic devices is configured to utilize outer wall focusing for high volume fraction microfiltration of particles. In an embodiment, multiple inertial microfluidic devices are connected in sequence for combined inner wall and outer wall focusing. The scalable method for manufacture of the inertial microfluidic device includes micromachining on a polycarbonate-based substrate a rectangular spiral microchannel having one or more input channels and a plurality of output channels configured to utilize high volume fraction outer wall focusing for microfiltration of particles.

This invention relates to a method for producing an alkenyl 1-aminocyclopropane-1-carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B is R and when A is R, B is S. The method comprises a stereoselective formation of the cyclopropane moiety by cycloaddition onto a double bond, in a molecule comprising a chiral template, Formula lc. Further provided is the use of Formula I in the production of stapled peptides.

Anti-PD-1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.

The present invention relates to antisense oligonucleotides for modulating the activity of glycine decarboxylase (GLDC). In particular, the present invention relates to antisense oligonucleotides capable of inducing exon skipping of RNA. Also claimed are pharmaceutical compositions, kits and methods of treating cancer and inducing exon-skipping using said antisense oligonucleotides. In addition, a method for aiding the categorising or determining prognosis of a cancer or in selecting a therapeutic strategy for a patient with cancer, based on assessing the level of GLDC nucleic acid, protein or activity in a sample derived from the patient is provided.

The present application discloses a surface-enhanced Raman scattering (SERS)-active photonic crystal fiber (PCF) probe including a biopsy needle in the PCF probe for integrated sample collection and SERS sensing of one or more analytes comprised in the sample. The PCF comprises solid core and a cladding region surrounding the solid core, wherein the cladding region comprises air holes functionalised by metallic nanoparticles. The application also provides a method for detecting one or more analytes using the PCF probe as well as the use of the PCF probe for the detection of one or more analytes.

Disclosed is a computer system for alerting emergency services. The system comprises a monitoring device, a at least one physical symptom device, a transmitter, a processor, and memory. The memory stores a predetermined baseline for one or more vital signs of a patient, a physical symptom baseline, each physical symptom baseline corresponding to a device of the physical symptom device. The memory stores instructions that cause the monitoring device to measure vital signs of the patient, compare the vital sign(s) to the respective predetermined baseline for the one or more vital signs, and if the measured vital sign(s) exceed the predetermined baseline, detect one or more physical symptoms corresponding to the physical symptom baseline The instructions cause the processor to compare the one or more physical symptoms to the respective physical symptom baseline, and initiate contact of emergency services using the transmitter, if at least one of physical symptoms deviates from the respective physical symptom, detect one or more physical symptoms corresponding to the physical symptom baseline. The instructions cause the processor to compare the one or more physical symptoms to the respective physical symptom baseline, and initiate contact of emergency services using the transmitter, if at least one of physical symptoms deviates from the respective physical symptom.

Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis-silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.

Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.