IMPEDIMETRIC BIOSENSOR
 | KEY INFORMATION TECHNOLOGY READINESS LEVEL: TRL3 |
| Patents: | A Nanogap Biosensing Electrode Design, SG Provisional Application filed, 10202300557R, 2023 |
| Know-How: | Off surface matrix for on-chip electrochemical ELISA, IME Know How PAT14-052/BEP-005, 2017 |
| Publication: | Multi-Cell Array of Nanogap Electrodes for Label-free Detection of Biomolecules, IEEE ECTC 2023 |
Overview
There is an increasing demand for self-testing kits. The requirements come from a diverse population of society for various applications such as infectious disease detection, pregnancy testing, ovulation tracking, etc. The reliable self-testing kits ensure early detection of the disease and reduce anxiety. Conventionally, laboratory-based ELISA testing comes with significant downsides due to longer waiting time and cost per use. Thus, it creates a need for point-of-care technology or user-friendly self-testing kits.
The molecular sensing platform was developed as a one-stop solution for detecting multi-biomarkers on the same device. The solution is also integrated with readout circuit with LED display. The solution utilizes biological activity for infectious disease detection and does not require measurement of the static environment in advance.
TECHNOLOGY FEATURES & SPECIFICATIONS
• The device provides rapid results (< 3 mins)
• The device provides a resolution of femto molar detection range
• The device requires an analyte volume of <20 µL
• The solution provides quantitative analysis of the bio-specimen as a replacement for conventional ELISA
• The solution is a label-free and muti-specimen biomarker detection
• The device is cost-effective
POTENTIAL APPLICATIONS
• Infectious disease detection (influenza virus, dengue virus, SARS CoViD, etc.)
• Pregnancy detection
• Ovulation tracking
• Wound healing tracking
• Quantification of severity of cancer
• Water sample analysis
• Early Dementia detection using Amyloid Beta (Aβ) biomarkers
UNIQUE VALUE PROPOSITION
• The competitive technology utilizes nanoparticles-based tagging for detection which increases the sample preparation time.
• The multi-purpose molecular sensing platform can be customized for various applications by changing the aptamer based on the target molecule of interest.
• The form factor of the device technology is easy to use.
• The cost of the device can be cheaper than existing devices.
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