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Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.

A METHOD OF SYNTHESIZING CELLULOSE CARBONATE According to the present disclosure, a method of synthesizing cellulose carbonate is provided. The method includes mixing a solution comprising dimethyl sulfoxide and cellulose with an organic base in the presence of carbon dioxide to form a cellulose solution comprising cellulose carbonate anions, wherein the organic base is represented by a formula of: R4 R5 wherein each of Ri, R2 and R3 is C1-C20 alkyl; and wherein each of R4 and R5 is hydrogen or C1-C20 alkyl. The method also includes contacting the cellulose solution with one or more organochlorides in the presence of carbon dioxide to form the cellulose carbonate, and adding an alcohol or water to precipitate the cellulose carbonate. No Figure

There is provided a sensing device for measuring a level of an analyte. The sensing device includes a sensing element configured to sense the analyte and produce an electrical output which is variable based on the level of the analyte sensed, a measurement circuit including a reference element for providing an electrical property, the measurement circuit being connected to the sensing element and configured to provide a measurement output signal based on the electrical property of the reference element and the electrical output of the sensing element, whereby the measurement output signal indicates the level of the analyte sensed with respect to the electrical property of the reference element. There is also provided a corresponding method of fabricating the sensing device.

A method and devices for controlling a potentiostat control loop circuit to provide an accurate cell voltage for electrochemically sensing a sample, wherein the cell voltage corresponds to a difference between electrode voltages a working electrode and a reference electrode of a three-electrode potentiostat are provided. The devices include a potentiostat control loop circuit having a first amplifier with an output connected to a counter electrode of the three electrode potentiostat and a first input connected to a first potential and a first switched capacitor network including a first capacitance device having a first electrode connected to a second input of the first amplifier. The first switched capacitor network is also operatively connected to the first amplifier for operating in a first mode and a second mode t switchably couple the second input of the first amplifier to the reference electrode of the three-electrode potentiostat. The method includes the step of, in the second mode, coupling the second input of the first amplifier to the reference electrode of the three-electrode potentiostat via the first capacitance device by coupling a second electrode of the first capacitance device to the reference electrode of the three-electrode potentiostat.

The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the prevention and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, autoimmune diseases, metabolic diseases, and neurodegenerative diseases (e.g. autism, autism spectrum disorders, Alzheimer's disease)), as well as methods of treating these diseases.

Various aspects of this disclosure provide a method of encrypting data in a network system. The method may include generating within a trusted network of the network system an associated private key based on an attribute associated with an user, a homomorphically encrypted associated private key based on the associated private key via homomorphic encryption, and a homomorphic key pair. The method may also include transmitting the homomorphically encrypted associated private key from the trusted network to a non-trusted network of the network system. The method may further include generating within the trusted network encrypted data based on said data, and a homomorphically and attribute based encrypted control key. The method may further include transmitting the encrypted data, and the homomorphically and attribute based encrypted control key, from the trusted network to the non-trusted network.

The present invention relates to a microarray device for detecting a target molecule such as miRNA in a sample. The device comprises a carrier substrate such as glass, an anti-fouling polymer layer which is functionalised with N-Hydroxysuccinimide (NHS) or carboxyl-groups and a capture probe. In an embodiment, the capture probe is an oligonucleotide with a stem-loop structure. The invention further defines a method for fabricating the device, a kit for detecting the target nucleic acid molecule comprising the device and a detection probe.

Methods for reduction of aggregate levels in antibody and other protein preparations through treatment with low concentrations of electropositive organic additives (e.g., ethacridine, chlorhexidine, or polyethylenimine) in combination with ureides (e.g., urea, uric acid, or allantoin) or organic modulators (e.g., nonionic organic polymers, surfactants, organic solvent or ureides). Some aspects of the invention relate to methods for reducing the level of aggregates in conjunction with clarification of cell culture harvest. It further relates to the integration of these capabilities with other purification methods to achieve the desired level of final purification.

Anti-PD-L1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and methods of using such antibodies to restore T-cell function in T-cells exhibiting T-cell exhaustion or T-cell anergy.

A coating comprising a metal-organic framework, wherein the metal-organic framework having a zeolitic structure comprising at least one multivalent metal species and at least one organic ligand (such as zeolitic imidazolate framework (ZIF)). Said coating has a topography comprising an array of projections, and each projection having at least one tapered distal end. There is also provided a method of coating substrates with the disclosed coating and use of said coating as a disinfectant, an antiseptic, or an antibiotic. Such use is possible because the tapered distal end of the disclosed zeolitic structure exerting higher pressure on any microbial cell that comes into contact with the disclosed coating, thereby piercing through the cell membrane more easily, causing cell deformation and lysis.