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The present invention relates to a pharmaceutical composition comprising a histone-lysine N-methyltransferase EZH2 (enhancer of zeste homolog 2) inhibitor and an enhancer of interferon-gamma receptor activity. The invention also relates to method of treating a patient having cancer, comprising administration of the pharmaceutical composition.

A method of purifying a sample containing a desired protein includes the steps of (i) providing a packed chromatographic column having positively charged porous particles, (ii) equilibrating the column to the conditions to which the desired protein in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the positively charged porous particles within the packed chromatographic column, (iv) eluting the desired protein from the packed chromatographic column, where the desired protein is in a purer state and in the conditions to which the packed chromatographic column was equilibrated; where the desired protein is an antibody, an antibody fragment, an antibody derivative, or an antibody fusion protein.

A method of purifying a sample that includes a polynucleotide includes the steps of (i) providing a packed chromatographic column having negatively charged porous particles, (ii) equilibrating the column to the conditions to which the polynucleotide in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the negatively charged porous particles within the packed chromatographic column, (iv) eluting the polynucleotide from the packed chromatographic column, where the polynucleotide is in a purer state and in the conditions to which the packed chromatographic column was equilibrated.

A method for manufacturing polycaprolactone microcarriers is disclosed together with uses of the microcarriers.

An optical waveguide device includes a substrate; a lower cladding disposed on the substrate; a rib waveguide including a slab disposed on the lower cladding and a single rib disposed on the slab contiguous to the slab; and an upper cladding disposed on the rib waveguide. The rib waveguide includes a first doped region having a first electric conductivity exhibiting a P-type electric conductivity across the rib and the slab and a second doped region being contiguous to the first doped region and having a second electric conductivity exhibiting an N-type electric conductivity across the rib and the slab.

A glycopeptide, comprising a polyproline backbone and one or more carbohydrate molecules.

There is provided a process for producing metal-containing particles, comprising the steps of forming a reaction mixture comprising (i) a metal salt, and (ii) a reaction medium comprising capping agent; and subjecting the reaction mixture to heat conditions to enable the formation of elemental metal, thereby forming the metal-containing particles. There is also provided a thermally conductive composition comprising a heat transfer medium and the disclosed metal-containing particles, and methods for its preparation.

We describe the use of an exosome for the preparation of a pharmaceutical composition to promote or enhance would healing or hair growth, or both, in an individual. The exosome may be derived from a stem cell such as a mesenchymal stem cell (MSC).

According to various embodiments, a spectrum coordination device may be provided. The spectrum coordination device may include: a memory configured to store working channel information indicating for each radio communication device of a plurality of radio communication devices information of at least one channel used by the respective radio communication device; a radio communication device information receiver configured to receive working channel update information of at least one radio communication device of the plurality of radio communication devices; a conflict determination circuit configured to determine whether there is a conflict of channels to be used by the plurality of radio communication devices based on the working channel information and the working channel update information; and a working channel information updating circuit configured to update the working channel information based on the determination of the conflict determination circuit.

The objective of the invention is to suppress, in a case of applying the RRH system in an environment having a plurality of cells (multi-cellular environment), the reduction of the throughput of the whole system. A base station, in the RRH system in which a plurality of antenna ports are dispersively placed in each of a plurality of cells, comprises: a selection unit that selects antenna ports, to which user terminals are to connect, from among the antenna ports of the cells in which the user terminals are existent; and a power setting unit that controls the transmission powers of the antenna ports. The selection unit and power setting unit set predetermined conditions for the target SINRs(t) of the user terminals and the transmission powers of the antenna ports, and select the antenna ports for the user terminals and control the transmission powers of the antenna ports such that the smallest one of the values of the SINRs of the user terminals of the plurality of cells is maximized.