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Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them.

Disclosed is an isolated antibody or an antigen-binding fragment thereof The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.

A cognitive training method has a step of obtaining sensor data of a subject during a memory exercise which in turn determines whether the sensor data includes predetermined information indicative of cognitive functions used for remembering. The step of advancing the memory exercise is carried out when it is determined that the sensor data includes predetermined information indicative of cognitive functions used for remembering. The step of calculating an objective cognitive assessment of the subject is carried out when the memory exercise is completed and cognitive training is measured at least partially in response to the advancing of the memory exercise. The fact that an objective cognitive assessment is calculated provides a method of using an autodidactic cognitive training device.

The invention relates to a sensor for sensing an analyte. The sensor comprises a detection sensing element having an electrical property variable with the amount of optical light received by the detection sensing element, a control sensing element having an electrical property variable with the amount of optical light received by the control sensing element, a detection optical element for contacting an analyte and transmitting a first amount of optical light received thereby to the detection sensing element in response to the contact with the analyte, a control optical element for contacting a control medium and transmitting a second amount of optical light received thereby to the control sensing element in response to the contact with the control medium, and an output arrangement configured to provide an indication based on the electrical property of the detection sensing element when the first amount of optical light is received by the detection sensing element, with respect to the electrical property of the control sensing element when the second amount of optical light is received by the control sensing element, thereby sensing said analyte. In various embodiments, the sensor is a pH sensor and electrical resistance is the electrical property variable in response to the amount of optical light received by the sensing elements.

There is provided an irreversible, colorimetric, oxidant-dependent time indicator comprising: a) a porous material substrate; b) one or more redox-active dyes; c) one or more reductants; d) one or more non-alkaline additives; characterized in that the components b) to c) are deposited on the substrate a) substantially in the absence of a polymeric material or thickener in the component matrix and substantially in the absence of an oxidant semipermeable coating layer on the substrate. There is also provided a method of using the indicator, a process for making the indicator, a device comprising one or more of the indicators and a kit of parts comprising the device.

A memory device and method comprising a metal oxide material disposed between and in electrical contact with first and second conductive electrodes, and a voltage source configured to apply a plurality of voltage pulses spaced apart in time across the first and second electrodes. For each one of the voltage pulses, an amplitude of the voltage increases during the voltage pulse.

This invention refers to an antibody or an antigen binding portion thereof, that binds specifically to human corneal endothelial cells (hCENCs), wherein the target of the monoclonal antibody, or antigen binding portion thereof, is essentially cell surface-expressed Peroxiredoxin-6 (Prdx6), as well as to methods for determining suitability of a cell sample for corneal transplantation, for quantitative enrichment of human corneal endothelial cells from a mixture of cells, and for isolating human corneal endothelial cells from a mixture of cell.

There is provided a method for culturing a stem cell in vitro. The method comprises providing a substrate surface coated with a coating comprising a molecule having a catechol moiety or a polymer thereof; and growing a stem cell on said coated substrate surface in a growth medium.

An implant having an adhesive structure comprising a planar surface having two sides and rectangular cuboid-based protrusions having pyramidal tips extending from at least one of said sides, optionally having a porous basic supporting structure, and methods of making and using such implants.

Methods are provided for enhancing reduction of virus and viral DNA levels in protein preparations.