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RESEARCH

Prof Chow leads the Program in Clinical and Translational Liver Research at the National Cancer Center Centre and is Protocol Chair of the Asia-Pacific Hepatocellular Carcinoma Trials Group. His research interests are in hepatocellular carcinoma and steato-hepatitis.

1. Clinical Trials and outcomes research in hepato-pancreato-biliary cancers
2. The genomics and immunology of hepatocellular carcinoma and the applications to personalized medicine
3. Brachytherapy and novel delivery platforms in solid organ cancers.
4. Patient tumour-explant xenografts and novel models in experimental oncology.
5. Metabolic liver disease and the microbiome

Selected Publications

• Li F, Huynh H, Li X et al. FGFR-Mediated Reactivation of MAPK Signaling Attenuates Antitumor Effects of Imatinib in Gastrointestinal Stromal Tumors. Cancer Discovery 2015. (IF: 19.453)
• Lim, K. C., Wang, V. W., Siddiqui, F. J., Shi, L., Chan, E. S., Oh, H. C., Tan, S. B., and Chow, P. K. (2014) Cost-effectiveness analysis of liver resection versus transplantation for early hepatocellular carcinoma within the Milan criteria, Hepatology. (IF:11.065)
• Chow, P. K., Poon, D. Y., Khin, M. W., Singh, H., Han, H. S., Goh, A. S., Choo, S. P., Lai, H. K., Lo, R. H., Tay, K. H., Lim, T. G., Gandhi, M., Tan, S. B., and Soo, K. C. (2014) Multicenter phase II study of sequential radioembolization-sorafenib therapy for inoperable hepatocellular carcinoma, PloS one 9, e90909. (IF: 3.234)
• Xu, Q., Leong, J., Chua, Q. Y., Chi, Y. T., Chow, P. K., Pack, D. W., and Wang, C. H. (2013) Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for treatment of human hepatocellular carcinoma, Biomaterials 34, 5149-5162. (IF:8.557)
• Chan-On, W., Nairismagi, M. L., Ong, C. K., Lim, W. K., Dima, S., Pairojkul, C., Lim, K. H., McPherson, J. R., Cutcutache, I., Heng, H. L., Ooi, L., Chung, A., Chow, P., Cheow, P. C., Lee, S. Y., Choo, S. P., Tan, I. B., Duda, D., Nastase, A., Myint, S. S., Wong, B. H., Gan, A., Rajasegaran, V., Ng, C. C., Nagarajan, S., Jusakul, A., Zhang, S., Vohra, P., Yu, W., Huang, D., Sithithaworn, P., Yongvanit, P., Wongkham, S., Khuntikeo, N., Bhudhisawasdi, V., Popescu, I., Rozen, S. G., Tan, P., and Teh, B. T. (2013) Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers, Nature genetics 45, 1474-1478. (IF: 29.352)
• Lim, K. C., Chow, P. K., Allen, J. C., Siddiqui, F. J., Chan, E. S., and Tan, S. B. (2012) Systematic review of outcomes of liver resection for early hepatocellular carcinoma within the Milan criteria, The British Journal of Surgery 99, 1622-1629. (IF: 5.21)
• Huynh, H., Chow, P. K., Tai, W. M., Choo, S. P., Chung, A. Y., Ong, H. S., Soo, K. C., Ong, R., Linnartz, R., and Shi, M. M. (2012) Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma, Journal of Hepatology 56, 595-601. (IF: 11.336)
• Lim, K. C., Chow, P. K., Allen, J. C., Chia, G. S., Lim, M., Cheow, P. C., Chung, A. Y., Ooi, L. L., and Tan, S. B. (2011) Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria, Annals of Surgery 254, 108-113. (IF: 8.327)
• Chow, P. K., Machin, D., Chen, Y., Zhang, X., Win, K. M., Hoang, H. H., Nguyen, B. D., Jin, M. Y., Lobo, R., Findlay, M., Lim, C. H., Tan, S. B., Gandhi, M., and Soo, K. C. (2011) Randomised double-blind trial of megestrol acetate vs placebo in treatment-naive advanced hepatocellular carcinoma, British Journal of Cancer 105, 945-952. (IF: 4.836)
• Eyles, J., Puaux, A. L., Wang, X., Toh, B., Prakash, C., Hong, M., Tan, T. G., Zheng, L., Ong, L. C., Jin, Y., Kato, M., Prevost-Blondel, A., Chow, P., Yang, H., and Abastado, J. P. (2010) Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma, The Journal of clinical investigation 120, 2030-2039. (IF: 13.261)